VitEse

VitESe is an aqueous emulsion of Vitamin E Acetate and selenium. It is an opalescent sterile solution for injection.

Composition
Each ml contains Vitamin E acetate 17 mg and Sodium Selenite 1,67 mg (equivalent to 0,67 mg of Selenium), preserved with Methyl Paraben 0.1 % and Propyl Paraben 0.0 I%.

Indications
VitESe is indicated for the treatment or prophylaxis of vitamin E and Selenium deficiency syndrome (also known as selenium-vitamin E responsive diseases). Available evidence suggests that dietary Selenium, Sulphur-containing amino acids and Vitamin E act synergistically to protect tissues from oxidative damage¹.

Selenium and/or vitamin E deficiency has been shown to impair the immune response in several species of animals and increases the severity of coliform mastitis in dairy cattle. Vitamin E has antioxidant properties: in combination with Selenium it protects against red blood cell haemolysis and prevents the action of peroxidase on unsaturated bonds in cell membranes. There is a growing body of evidence showing that selenium and Vitamin E are important factors in the immune response of animals². Vitamin E can stimulate the immune defence mechanism in laboratory animals and this effect has been recorded in cattle¹. Studies have indicated that selenium may enhance the resistance of the bovine mammary gland to infectious agents ^4*

The essential role of Selenium is as part of the enzyme Glutathione Peroxidise, which prevents free radical damage to tissues.

VitESe is indicated as an aid in the prevention of the following disorders:

• Bovine: Nutritional muscular dystrophy; retained foetal membranes; resistance to mastitis.
  Porcine: Hepatosis dietetica; exudative diathesis; iron hypersensitivity; nutritional muscular dystrophy; anaemia.
• Ovine: Nutritional muscular dystrophy; bone marrow abnormalities.
• Poultry: Growth delay and myopathies.

Precautions
Acute and chronic selenium toxicity can occur in horses and is usually due to excessive supplementation. VitESe should only be used in species for which it is indicated. Do not use in pregnant animals. Do not administer IV. Withdrawal period: Cattle, sheep and pigs. Meat: 28 days. Milk: 5 days.

Directions For Use
Intramuscular Injection

	PROPHYLACTIC	THERAPEUTIC
Calves	2-4 ml	4-8 ml
Ewes	2-3 ml
Pigs	3-5 ml	6-10 ml
Piglets / Lambs	0.5 ml	1 ml
Horse / Cattle	3,l/100 kg bm	–

Oral Administration
Poultry: 1 ml/ 100 chickens dissolved in drinking water

Packing
100 ml multidose vial

Storage
Store at or below room temperature (not more than 25° C) and protect from light.

Registration Number
G3397 Act36/ 1947

1. Koller, L.D. & Exon, J.H. (1986) CanJ.Vetres. 50,297.
2. Kiremidijian-Schumacher, L & Stotzky, G. ( 1987) Environ.Res, 42,277
3. Pehrson, D et al 1991) /. dairy Sci., 74, I 054
4. Erskine RJ et al ( 989),Am.J. vet Res. SO, 2093