A potentiated sulphonamide injection with a potent antibacterial action.

Composition
Sterile solution containing Sulphamethoxazole 200mg/ml and Trimethoprim 40mg/ml. Preservative: benzyl alcohol 2%.
KYROTRIM is indicated for use in cattle, sheep and pigs to treat sulphonamide sensitive infections. It is used to treat
bacterial infections of the respiratory tract, gastrointestinal tract and urinary tract as well as wound infections and
footrot.

Discusssion
Sulphonamides combined with dihydrofolate reductase inhibitors, e.g. trimethoprim, constitute a useful class of drugs for the treatment of bacterial infections. Dihydrofolate reductase inhibitors inhibit the conversion of bacterial
dihydrofolic acid to tetrahydrofolic acid which is necessary for the synthesis of certain amino acids, purines, and DNA synthesis. Because they act at different points of the folate metabolic pathway a potent synergy exists between these
reductase inhibitors and the sulphonamides, with an increase of up to about 10-fold in antibacterial activity, and a bactericidal action where the components individually are generally bacteriostatic. The combination exerts its selective
action because of a far greater affinity for the bacterial than the mammalian enzyme. The sulphamethoxazole / trimethoprim combination used in KYROTRIM has been used in a wide variety of infections caused by susceptible
organisms, particularly those of the urinary, respiratory, and gastrointestinal tracts. The antibacterial spectrum of the combination is broad and includes a high proportion of anaerobic bacteria, Nocardia, Chlamydia, and Toxoplasma spp.
Potentiated sulphonamides have repeatedly been shown to be therapeutically useful in treating veterinary microbial infections in both small and large animals. They have been used to treat susceptible bacterial populations (including
Staphylococcus spp.) in the skin, both topically and systemically. Potentiated sulphonamides are effective against many Staphylococcal spp. and gram-negative rods and are used extensively in the treatment of canine pyoderma.

Dosage
By intramuscular injection 1 ml per 15 kg body mass daily for 5 days. In cases of severe infection the dose can be increased to 1,5 ml per 15 kg body mass.

Warnings
Withdrawal period: Meat: 5 days. Milk: 3 days. May cause swelling at the site of injection. Do not use in animals with
liver disease. Do not use in animals with known sulpha drug sensitivity. Keep out of reach of children, animals and
uninformed persons. IV administration of potentiated sulphonamides may precipitate collapse in horses and cattle.

Packaging

100ml amber injection vials (sterile)

Stirage
Store at room temperature below 25°C and away from light.

Registration number
G3426 Act 36/1947

Bibliography:
1. Martindale 33/e, pub. The Pharmaceutical Press, 2002.
2. Veterinary Pharmacology and Therapeutics 8/e, pub. Iowa State University, 2001