DEBRIZYME is  an  aerosol wound dressing spray.  DEBRIZYME aids in  the treatment of external wounds and also assists healing through debridement and by stimulation of epithelial tissue.

COMPOSITION
Each gram of DEBRIZYME contains 0, 125g trypsin crystalline, 290mg castor oil, 40mg peru balsam, 200i.u. vitamin A and Si.u.vitamin E.

DISCUSSION

• Trypsin is a proteolytic enzyme and acts as a mild  debriding agent.  It is  effective  in  the  removal of necrotic tissue, exudate and coagulated blood.
• Peru balsam is used to increase circulation  in  the  wound  site  area  by  dilation  of the  blood vessels. Increasing the local blood  flow brings  nutrients  and  oxygen  needed  for re- epithelialisation to the wound much faster and this also  means a more rapid  removal  of products of skin necrosis. Peru balsam also  has  a mild  bactericidal  action  and  promotes wound granulation.
• Castor oil increases epithelialisation. It reduces premature epithelial dehydration and keratinisation.
• Miyamoto has demonstrated an acceleration of cell renewal and wound healing with topically applied vitamin A  and vitamin  E1 •
• There are no adverse skin/cell reactions association with the application of DEBRIZYME.

DIRECTIONS FOR USE
Shake the can before use. Use the extension nozzle supplied to spray directly onto the wound site. Apply 2-3 times a day. Avoid spraying into eyes and on fresh arterial clots. 

PACKING
150ml aerosol can with extension nozzle.

STORAGE
Store at room temperature (below 25 °C ).

REGISTRATION NUMBER
G 1791 Act 36/1947

I. Miyamoto L, et al. Effects of cosmetics containing bioactive substances on skin. Proceedings of the 14th IFSCC Congress. Barcelona 1986.

WOUND HEALING STUDY
Three cases showing open wounds were brought in for treatment. Two were dogs,  both  of which  had  necrotic, contaminated open wounds.  Dog  I  had  been  in  a dog  fight  and  had  had  a piece  of flank  removed;  Dog 2 had  been  hit by a car and suffered a dorsal degloving wound to the left front paw. Both cases were treated  with  a course  of oral antibiotics (amoxicillin/clavulanic acid).The wounds were cleaned and sprayed with DEBRl2YME (Kyron).Acriflavine in Glycerin (Kyron) was then applied and the wound covered with a dressing.The dressings were changed daily and DEBRl2YME was sprayed on the wound before each application of Acriflavine in Glycerin.

Dog 1

Day 1

Day 4

Day 9

Dog2

Day 1

Day 7

Day /6

A cat, the third case, presented with a wound on its left flank which had been left untreated for some time. The resulting abscess burst, leaving a gaping open wound.The cat was treated with a course of oral antibiotics (amoxicillin/clavulanic acid) and DEBRIZYME alone applied daily.

Cat

Day 1

Day 1

DEBRlZYME chemically debrides necrotic tissue and stimulates growth  of epithelial  tissue,  which  accelerates  the wound healing process. Trypsin, the debriding agent, is especially important in the first few days when the wound is contaminated and filled with necrotic tissue. Castor oil and  peru  balsam  also  speed  up  epithelialisation.  The overall effect is an acceleration in wound healing, as can be seen by the healthy  granulation  tissue  evident  in  the  later photographs.

Acriflavine in Glycerin, with its mild antibacterial action, is very useful for the treatment  of contaminated  or infected wounds as it promotes wound drainage and has a hygroscopic effect.
All wounds continued to decrease in size with open wound management, and healed well.