DEBRIZYME is an aerosol wound dressing spray. DEBRIZYME aids in the treatment of external wounds and also assists healing through debridement and by stimulation of epithelial tissue.
Each gram of DEBRIZYME contains 0, 125g trypsin crystalline, 290mg castor oil, 40mg peru balsam, 200i.u. vitamin A and Si.u.vitamin E.
- Trypsin is a proteolytic enzyme and acts as a mild debriding agent. It is effective in the removal of necrotic tissue, exudate and coagulated blood.
- Peru balsam is used to increase circulation in the wound site area by dilation of the blood vessels. Increasing the local blood flow brings nutrients and oxygen needed for re- epithelialisation to the wound much faster and this also means a more rapid removal of products of skin necrosis. Peru balsam also has a mild bactericidal action and promotes wound granulation.
- Castor oil increases epithelialisation. It reduces premature epithelial dehydration and keratinisation.
- Miyamoto has demonstrated an acceleration of cell renewal and wound healing with topically applied vitamin A and vitamin E1 •
- There are no adverse skin/cell reactions association with the application of DEBRIZYME.
DIRECTIONS FOR USE
Shake the can before use. Use the extension nozzle supplied to spray directly onto the wound site. Apply 2-3 times a day. Avoid spraying into eyes and on fresh arterial clots.
150ml aerosol can with extension nozzle.
Store at room temperature (below 25 °C ).
G 1791 Act 36/1947
I. Miyamoto L, et al. Effects of cosmetics containing bioactive substances on skin. Proceedings of the 14th IFSCC Congress. Barcelona 1986.
WOUND HEALING STUDY
Three cases showing open wounds were brought in for treatment. Two were dogs, both of which had necrotic, contaminated open wounds. Dog I had been in a dog fight and had had a piece of flank removed; Dog 2 had been hit by a car and suffered a dorsal degloving wound to the left front paw. Both cases were treated with a course of oral antibiotics (amoxicillin/clavulanic acid).The wounds were cleaned and sprayed with DEBRl2YME (Kyron).Acriflavine in Glycerin (Kyron) was then applied and the wound covered with a dressing.The dressings were changed daily and DEBRl2YME was sprayed on the wound before each application of Acriflavine in Glycerin.
A cat, the third case, presented with a wound on its left flank which had been left untreated for some time. The resulting abscess burst, leaving a gaping open wound.The cat was treated with a course of oral antibiotics (amoxicillin/clavulanic acid) and DEBRIZYME alone applied daily.
DEBRlZYME chemically debrides necrotic tissue and stimulates growth of epithelial tissue, which accelerates the wound healing process. Trypsin, the debriding agent, is especially important in the first few days when the wound is contaminated and filled with necrotic tissue. Castor oil and peru balsam also speed up epithelialisation. The overall effect is an acceleration in wound healing, as can be seen by the healthy granulation tissue evident in the later photographs.
Acriflavine in Glycerin, with its mild antibacterial action, is very useful for the treatment of contaminated or infected wounds as it promotes wound drainage and has a hygroscopic effect.
All wounds continued to decrease in size with open wound management, and healed well.